Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study

J Diabetes Complications. 2019 Jun;33(6):434-436. doi: 10.1016/j.jdiacomp.2019.03.001. Epub 2019 Mar 21.

Abstract

Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Lower SUMOD correlated with aortic stiffness, suggesting its potential as a CVD biomarker in T1D.

Keywords: Adolescents; Aortic stiffness; Ascending aortic pulse wave velocity; Relative area change; Serum uromodulin; Type 1 diabetes.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aorta / diagnostic imaging
  • Aorta / physiology
  • Biomarkers / blood
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control
  • Child
  • Diabetes Mellitus, Type 1* / blood
  • Diabetes Mellitus, Type 1* / complications
  • Diabetes Mellitus, Type 1* / drug therapy
  • Diabetes Mellitus, Type 1* / physiopathology
  • Diabetic Angiopathies / blood
  • Diabetic Angiopathies / etiology
  • Diabetic Angiopathies / prevention & control
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Male
  • Metformin / therapeutic use
  • Pulse Wave Analysis
  • Risk Factors
  • Treatment Outcome
  • Uromodulin / blood*
  • Vascular Stiffness* / drug effects
  • Young Adult

Substances

  • Biomarkers
  • Uromodulin
  • Metformin