Hear Pancreatic Cancer Stem Cells ROR

Wantong Yao; Anirban Maitra

doi:10.1016/j.cell.2019.04.002

Hear Pancreatic Cancer Stem Cells ROR

Cell. 2019 Apr 18;177(3):516-518. doi: 10.1016/j.cell.2019.04.002.

Authors

Wantong Yao¹, Anirban Maitra²

Affiliations

¹ Department of Translational Molecular Pathology and Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. Electronic address: wyao22@mdanderson.org.
² Department of Translational Molecular Pathology and Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

PMID: 31002791
DOI: 10.1016/j.cell.2019.04.002

Abstract

In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.

Publication types

Comment

MeSH terms

Adenocarcinoma*
Gene Expression Regulation
Humans
Nuclear Receptor Subfamily 1, Group F, Member 3
Pancreatic Neoplasms*
Transcription Factors

Substances

Nuclear Receptor Subfamily 1, Group F, Member 3
Transcription Factors