The Ganoderma lucidum wood-degrading basidiomycete, with its large complex of pharmacological effects, is the most outstanding and influential medicinal mushroom in Far East traditional medicine. In the past 2 decades, the fundamentals of submerged cultivation of G. lucidum mycelia in bioreactors has been established. Development of comprehensive submerged cultivations in stirred tank and air lift bioreactors are the most promising technologies. This article provides an engineering overview of the achievements in submerged technology of G. lucidum biomass production in bioreactors.