Interaction of neurotransmitters and neurochemicals with lymphocytes

Daniel Kerage; Erica K Sloan; Stephen R Mattarollo; Pamela A McCombe

doi:10.1016/j.jneuroim.2019.04.006

Interaction of neurotransmitters and neurochemicals with lymphocytes

J Neuroimmunol. 2019 Jul 15:332:99-111. doi: 10.1016/j.jneuroim.2019.04.006. Epub 2019 Apr 11.

Authors

Daniel Kerage¹, Erica K Sloan², Stephen R Mattarollo³, Pamela A McCombe⁴

Affiliations

¹ The University of Queensland Diamantina Institute, Brisbane, Australia; Transplant Research Program, Boston Children's Hospital, Boston, MA, United States of America.
² Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; Division of Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Cousins Center for Neuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, USA.
³ The University of Queensland Diamantina Institute, Brisbane, Australia.
⁴ The University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Brisbane, Australia; Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia. Electronic address: pamela.mccombe@uq.edu.au.

PMID: 30999218
DOI: 10.1016/j.jneuroim.2019.04.006

Abstract

Neurotransmitters and neurochemicals can act on lymphocytes by binding to receptors expressed by lymphocytes. This review describes lymphocyte expression of receptors for a selection of neurotransmitters and neurochemicals, the anatomical locations where lymphocytes can interact with neurotransmitters, and the effects of the neurotransmitters on lymphocyte function. Implications for health and disease are also discussed.

Keywords: Immune regulation; Immunomodulation; Lymphocytes; Neural signaling; Neurotransmitters.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenosine / metabolism*
Animals
Bone Marrow / innervation
Brain / physiology
Endocannabinoids / metabolism*
Endorphins / metabolism*
Humans
Lymphocytes / metabolism*
Lymphoid Tissue / innervation
Neuroimmunomodulation / physiology*
Neurons / metabolism
Neurotransmitter Agents / metabolism*
Nociception / physiology
Receptors, Neurotransmitter / immunology
Receptors, Neurotransmitter / metabolism
Reward
Thymus Gland / innervation

Substances

Endocannabinoids
Endorphins
Neurotransmitter Agents
Receptors, Neurotransmitter
Adenosine