Effect of Acacia Honey on Transforming Growth Factor-Beta-1-Induced Myofibroblast Differentiation and Matrix Metalloproteinase-9 Production in Nasal Polyp Fibroblasts

Am J Rhinol Allergy. 2019 Sep;33(5):483-489. doi: 10.1177/1945892419843702. Epub 2019 Apr 18.

Authors

Seung-Heon Shin¹, Mi-Kyung Ye¹, Dong-Won Lee¹, Mi-Hyun Che¹

Affiliation

¹ 1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu, South Korea.

PMID: 30997818
DOI: 10.1177/1945892419843702

No abstract available

Keywords: acacia honey; extracellular matrix; matrix metalloproteinase-9; myofibroblast; nasal fibroblast.

MeSH terms

Acacia
Actins / genetics
Actins / metabolism
Biological Products / pharmacology*
Cell Differentiation / drug effects*
Cell Survival
Cells, Cultured
Fibroblasts / drug effects*
Fibroblasts / metabolism
Fibroblasts / pathology
Honey*
Humans
Matrix Metalloproteinase 9 / genetics
Matrix Metalloproteinase 9 / metabolism*
Nasal Polyps / pathology*
Phosphorylation / drug effects
Smad2 Protein / metabolism
Smad3 Protein / metabolism
Transforming Growth Factor beta1 / pharmacology*

Substances

ACTA2 protein, human
Actins
Biological Products
SMAD2 protein, human
SMAD3 protein, human
Smad2 Protein
Smad3 Protein
Transforming Growth Factor beta1
MMP9 protein, human
Matrix Metalloproteinase 9