The focus of this critical insight article is a brief overview of analytical challenges the cannabis industry faces and how analytical chemists have new opportunities to demonstrate the merits of employing mass spectrometry for the chemical analysis of cannabis and its products. The current range of cannabis products extends from recreational use to medicines, edibles, beverages, and beyond. The standards employed to assure product quality, integrity, and safety are lacking compared to those currently used by the pharmaceutical, food, and beverage industries. This manuscript overviews some of the important analytical issues that exist for the growth and harvest of the cannabis plant to the production of a wide variety of its products. Currently, the topics of interest for safety in cannabis testing where mass spectrometry can play an important role include what are currently referred to as potency, pesticides, terpenes, heavy metals, and mycotoxins from bacteria. Since each state in the USA as well as several countries has their own regulations, the analytical opportunities and challenges vary depending upon which jurisdiction a laboratory is supporting. This Critical Insight report will suggest where mass spectrometry can play an important role and provide valuable input on these topics. Graphical Abstract.
Keywords: GC/MS; LC/MS; LC/MS/MS; Mass Spectrometry; cannabis; hemp; marijuana.