Intake of arachidonic acid-containing lipids in adult humans: dietary surveys and clinical trials

Lipids Health Dis. 2019 Apr 16;18(1):101. doi: 10.1186/s12944-019-1039-y.

Abstract

Long-chain polyunsaturated fatty acids (LCPUFAs) have important roles in physiological homeostasis. Numerous studies have provided extensive information about the roles of n-3 LCPUFA, such as docosahexaenoic acid and eicosapentaenoic acid. Arachidonic acid (ARA) is one of the major n-6 LCPUFAs and its biological aspects have been well studied. However, nutritional information for ARA is limited, especially in adult humans. This review presents a framework of dietary ARA intake and the effects of ARA supplementation on LCPUFA metabolism in adult humans, and the nutritional significance of ARA and LCPUFA is discussed.

Keywords: Arachidonic acid; Dietary survey; Docosahexaenoic acid; Eicosapentaenoic acid; Long-chain polyunsaturated fatty acid.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Arachidonic Acid / administration & dosage*
  • Arachidonic Acid / blood
  • Clinical Trials as Topic
  • Diet / methods
  • Diet Surveys / statistics & numerical data
  • Dietary Supplements / analysis*
  • Docosahexaenoic Acids / administration & dosage*
  • Docosahexaenoic Acids / blood
  • Eicosapentaenoic Acid / administration & dosage*
  • Eicosapentaenoic Acid / blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Recommended Dietary Allowances

Substances

  • Docosahexaenoic Acids
  • Arachidonic Acid
  • Eicosapentaenoic Acid