SUMOylation in Glioblastoma: A Novel Therapeutic Target

Brandon M Fox; Andrew Janssen; Dagoberto Estevez-Ordonez; Florian Gessler; Nunzio Vicario; Gustavo Chagoya; Galal Elsayed; Houman Sotoudeh; William Stetler; Gregory K Friedman; Joshua D Bernstock

doi:10.3390/ijms20081853

SUMOylation in Glioblastoma: A Novel Therapeutic Target

Int J Mol Sci. 2019 Apr 15;20(8):1853. doi: 10.3390/ijms20081853.

Authors

Brandon M Fox^{1

2}, Andrew Janssen³, Dagoberto Estevez-Ordonez⁴, Florian Gessler⁵, Nunzio Vicario⁶, Gustavo Chagoya⁷, Galal Elsayed⁸, Houman Sotoudeh⁹, William Stetler¹⁰, Gregory K Friedman^{11

12

13}, Joshua D Bernstock^{14

15}

Affiliations

¹ Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. bmfox@uab.edu.
² Medical Scientist Training Program, University of Alabama at Birmingham, 1825 University Boulevard, SHEL 121, Birmingham, AL 35294, USA. bmfox@uab.edu.
³ Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. janssen@uab.edu.
⁴ Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. dagoestevez@gmail.com.
⁵ Department of Neurosurgery, University Hospital Frankfurt, Goethe-University, Schleusenweg 2-16, 60528 Frankfurt, Germany. flo.gessler@gmail.com.
⁶ Department of Biomedical and Biotechnological Sciences, Physiology Section, University of Catania, Via S. Sofia n. 97, Torre Biologica, 95123 Catania, Italy. vicarionunzio@gmail.com.
⁷ Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. gchagoya@uabmc.edu.
⁸ Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. gelsayed@uabmc.edu.
⁹ Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, Jefferson Tower N419-619 19th Street South, Birmingham, AL 35223, USA. HSotoudeh@uabmc.edu.
¹⁰ Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. wstetler@uabmc.edu.
¹¹ Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. GFriedman@peds.uab.edu.
¹² Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, Jefferson Tower N419-619 19th Street South, Birmingham, AL 35223, USA. GFriedman@peds.uab.edu.
¹³ Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Lowder 512, 1600 7th Avenue South, Birmingham, AL 35223, USA. GFriedman@peds.uab.edu.
¹⁴ Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA. jdb82@uab.edu.
¹⁵ Medical Scientist Training Program, University of Alabama at Birmingham, 1825 University Boulevard, SHEL 121, Birmingham, AL 35294, USA. jdb82@uab.edu.

Abstract

Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.

Keywords: SUMO1-3; SUMOylation; glioblastoma (GBM); post-translational modifications (PTMs).

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Antineoplastic Agents / therapeutic use
Brain / drug effects
Brain / metabolism
Brain / pathology
Brain Neoplasms / drug therapy*
Brain Neoplasms / metabolism*
Brain Neoplasms / pathology
Glioblastoma / drug therapy*
Glioblastoma / metabolism*
Glioblastoma / pathology
Humans
Molecular Targeted Therapy / methods
Protein Processing, Post-Translational / drug effects
Small Ubiquitin-Related Modifier Proteins / metabolism
Sumoylation / drug effects*

Substances

Antineoplastic Agents
Small Ubiquitin-Related Modifier Proteins

Grants and funding

P30 CA013148/CA/NCI NIH HHS/United States