Polyclonal predominance of concurrently producing OXA-23 and OXA-58 carbapenem-resistant Acinetobacter baumannii strains in a pediatric intensive care unit

Theodoros Karampatakis; Katerina Tsergouli; Lida Politi; Georgia Diamantopoulou; Elias Iosifidis; Charalampos Antachopoulos; Aggeliki Karyoti; Maria Sdougka; Athanassios Tsakris; Emmanuel Roilides

doi:10.1007/s11033-019-04744-4

Polyclonal predominance of concurrently producing OXA-23 and OXA-58 carbapenem-resistant Acinetobacter baumannii strains in a pediatric intensive care unit

Mol Biol Rep. 2019 Jun;46(3):3497-3500. doi: 10.1007/s11033-019-04744-4. Epub 2019 Apr 12.

Authors

Theodoros Karampatakis^{1

2}, Katerina Tsergouli², Lida Politi³, Georgia Diamantopoulou³, Elias Iosifidis^{1

4}, Charalampos Antachopoulos^{1

4}, Aggeliki Karyoti^{2

4}, Maria Sdougka⁵, Athanassios Tsakris³, Emmanuel Roilides^{6

7}

Affiliations

¹ Infectious Disease Unit, 3rd Department of Pediatrics, Medical Faculty, Aristotle University School of Health Sciences, Hippokration General Hospital, Konstantinoupoleos 49, 546 42, Thessaloniki, Greece.
² Microbiology Department, Hippokration General Hospital, Thessaloniki, Greece.
³ Microbiology Department, National and Kapodistrian University School of Medicine, Athens, Greece.
⁴ Infection Control Committee, Hippokration General Hospital, Thessaloniki, Greece.
⁵ Pediatric Intensive Care Unit, Hippokration General Hospital, Thessaloniki, Greece.
⁶ Infectious Disease Unit, 3rd Department of Pediatrics, Medical Faculty, Aristotle University School of Health Sciences, Hippokration General Hospital, Konstantinoupoleos 49, 546 42, Thessaloniki, Greece. roilides@med.auth.gr.
⁷ Infection Control Committee, Hippokration General Hospital, Thessaloniki, Greece. roilides@med.auth.gr.

PMID: 30989561
DOI: 10.1007/s11033-019-04744-4

Abstract

We report a predominance (64.7%) of polyclonal carbapenem-resistant Acinetobacter baumannii (CRAB) strains concurrently producing OXA-23 and OXA-58 carbapenemases in a pediatric intensive care unit in an endemic area. This is the first report of emergence of such double-OXA CRAB strains in a single unit worldwide.

Keywords: Acinetobacter baumannii; Carbapenems; Critical care; Microbial resistance; Pediatrics.

MeSH terms

Acinetobacter baumannii / drug effects*
Acinetobacter baumannii / metabolism*
Anti-Bacterial Agents / pharmacology
Bacterial Proteins / metabolism
Carbapenems / pharmacology*
Drug Resistance, Bacterial / immunology
Humans
Intensive Care Units, Pediatric
Microbial Sensitivity Tests
beta-Lactamases / metabolism

Substances

Anti-Bacterial Agents
Bacterial Proteins
Carbapenems
beta-Lactamases
carbapenemase