Hereditary gastric cancer: what's new? Update 2013-2018

Fam Cancer. 2019 Jul;18(3):363-367. doi: 10.1007/s10689-019-00127-7.

Abstract

Around 10-20% of gastric cancer patients have relatives with a diagnosis of GC and in 1-3% of patients a genetic cause can be confirmed. Histopathologically, GC is classified into intestinal-type, with glandular growth, and diffuse-type with poorly cohesive growth pattern often with signet ring cells. Familial or hereditary GC is classified into hereditary diffuse GC (HDGC), familial intestinal GC (FIGC) and polyposis forms. This review focuses on recent research findings and new concepts of hereditary GC.

Keywords: E-Cadherin; Hereditary diffuse gastric cancer; Stomach.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / genetics*
  • Antigens, CD / genetics*
  • Cadherins / genetics*
  • Family Health
  • Gene Silencing
  • Germ-Line Mutation
  • Humans
  • Polyps / genetics*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology
  • Syndrome
  • alpha Catenin / genetics

Substances

  • Antigens, CD
  • CDH1 protein, human
  • CTNNA1 protein, human
  • Cadherins
  • alpha Catenin