The Antiviral Apparatus: STING and Oncolytic Virus Restriction

Joel Lee; Mohammed G Ghonime; Ruoning Wang; Kevin A Cassady

doi:10.1016/j.omto.2019.02.002

The Antiviral Apparatus: STING and Oncolytic Virus Restriction

Mol Ther Oncolytics. 2019 Mar 20:13:7-13. doi: 10.1016/j.omto.2019.02.002. eCollection 2019 Jun 28.

Authors

Joel Lee¹, Mohammed G Ghonime², Ruoning Wang², Kevin A Cassady^{2

3

4}

Affiliations

¹ The Ohio State University College of Medicine, Biomedical Sciences Graduate Program, Columbus, OH 43210, USA.
² The Research Institute at Nationwide Children's Hospital Center for Childhood Cancer and Blood Disorders, The Ohio State University, Columbus, OH, USA.
³ Nationwide Children's Hospital, Department of Pediatrics, Division of Pediatric Infectious Diseases, Columbus, OH, USA.
⁴ The Ohio State University, Department of Pediatrics, Columbus, OH, USA.

Abstract

A network of pattern recognition receptors (PRRs) is responsible for the detection of invading viruses and acts as the trigger for the host antiviral response. Central to this apparatus is stimulator of interferon genes (STING), which functions as a node and integrator of detection signals. Owing to its role in both intrinsic and adaptive immunity, STING has become a focus for researchers in the field of oncolytic virotherapy. In this review, we consider the function of the cGAS-STING axis and its regulation, both by cellular mechanisms and as a result of viral interference.

Keywords: HSV; IFI16; STING; cGAS; cancer; immunotherapy; interferon; oncolytic virotherapy.

Publication types

Review

Abstract

Publication types

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