Abstract
We report the engineering of a protein-based dynamic hydrogel that can be reversibly tuned between stiff and soft states via a redox reaction. When cultured on this hydrogel surface, human lung fibroblasts can dynamically and reversibly change their morphology in response to changes in hydrogel stiffness.
MeSH terms
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Cell Culture Techniques / methods
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Cell Line
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Cell Proliferation / drug effects
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Elastic Modulus / physiology*
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Extracellular Matrix / metabolism
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Fibroblasts / cytology*
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Humans
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Hydrogels / metabolism*
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Kinetics
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Lung / metabolism*
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Oxidation-Reduction
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Protein Binding / drug effects
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Protein Conformation / drug effects
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Protein Engineering / methods
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Proteins / metabolism*