Objective: To summarize the research progress on the calcitonin gene-related peptide (CGRP) and receptor activator of nuclear factor κB (RANK)/receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) system during bone reconstruction to provide theoretical basis for further research on the prevention and treatment of bone-related diseases.
Methods: The relevant research results at home and abroad in recent years were analyzed and summarized.
Results: CGRP and RANK/RANKL/OPG system play important regulatory roles in the bone reconstruction.
Conclusion: At present, the research on the mechanism of CGRP and RANK/RANKL/OPG system in bone reconstruction is insufficient. Therefore, it is necessary to study further on the process and interrelation of CGRP and RANK/RANKL/OPG system in bone reconstruction to confirm their mechanism, which will bring new ideas and methods for the treatment of bone related diseases in clinic.
目的: 总结骨重建过程中降钙素基因相关肽（calcitonin gene-related peptide，CGRP）与核因子 κB 受体活化因子（receptor activator of nuclear factor κB，RANK）/核因子 κB 受体活化因子配体（receptor activator of nuclear factor κB ligand，RANKL）/骨保护蛋白（osteoprotegerin，OPG）信号系统作用机制的研究进展，为进一步研究骨相关疾病的预防及治疗提供理论依据。.
方法: 广泛查阅国内外近年来骨重建过程中 CGRP 与 RANK/RANKL/OPG 信号系统相关文献，并加以分析总结。.
结果: 骨重建过程中，CGRP 与 RANK/RANKL/OPG 信号系统发挥着重要调控作用。.
结论: 目前对于骨重建过程中 CGRP 与 RANK/RANKL/OPG 信号系统的作用机制研究仍不够深入，需进一步研究二者在骨重建过程中的具体作用方式、相互联系，明确作用机制，为临床上骨相关疾病的治疗带来新思路、新方法。.
Keywords: Bone reconstruction; calcitonin gene-related peptide; osteoblast; osteoclast; osteoprotegerin; receptor activator of nuclear factor κB; receptor activator of nuclear factor κB ligand.