Deterioration of Brain Neural Tracts in Elderly Women with Sarcopenia

Abstract

Objectives: Sarcopenia is known to be associated with increased stiffness in brain arteries, which causes deterioration in brain structure and function. In this study, the authors evaluated the deterioration of neural tracts using diffusion tensor tractography (DTT) in elderly women with sarcopenia and investigated whether deterioration of neural tracts is consistent with clinical findings.

Methods: Twenty elderly women with sarcopenia were recruited. Muscle mass was measured by dual energy x-ray absorptiometry. Hand-grip power and gait speed were also assessed. Memory function was evaluated using the Seoul Neuropsychological Screening Battery. Additionally, using DTT-Studio software, the authors evaluated eight neural tracts: the corticospinal tract (CST), corticoreticular pathway, fornix, cingulum, superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and optic radiation. The authors measured the DTT parameters (fractional anisotropy [FA] and fiber volume [FV]) for each neural tract.

Results: The FA and FV values were decreased in all the evaluated neural tracts, compared with those of the 20 normal comparison subjects. The FVs of the CST were significantly correlated with the hand-grip power of elderly women with sarcopenia. The FVs of the fornix and cingulum in elderly women with sarcopenia were significantly correlated with their memory function.

Conclusion: The authors found that the neural tracts in elderly women with sarcopenia were extensively deteriorated, and their hand-grip power and memory function were associated with related neural tracts. The DTT seems to be a useful tool for evaluating structural changes in the brains of people with sarcopenia.

Keywords: Sarcopenia; brain; diffusion tensor imaging; diffusion tensor tractography; hand-grip power; memory.