Thrombotic microangiopathies during pregnancy: The obstetrical and neonatal perspective

Laura Sarno; Vedran Stefanovic; Giuseppe M Maruotti; Fulvio Zullo; Pasquale Martinelli

doi:10.1016/j.ejogrb.2019.03.018

Thrombotic microangiopathies during pregnancy: The obstetrical and neonatal perspective

Eur J Obstet Gynecol Reprod Biol. 2019 Jun:237:7-12. doi: 10.1016/j.ejogrb.2019.03.018. Epub 2019 Mar 23.

Authors

Laura Sarno¹, Vedran Stefanovic², Giuseppe M Maruotti³, Fulvio Zullo³, Pasquale Martinelli³

Affiliations

¹ Department of Neurosciences, Reproductive and Dentistry Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy. Electronic address: laura.sarno@unina.it.
² Department of Obstetrics and Gynecology, Fetomaternal Medical Center, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 2, 00290, Helsinki, Finland.
³ Department of Neurosciences, Reproductive and Dentistry Sciences, University Federico II, Via Pansini 5, 80131, Naples, Italy.

PMID: 30978582
DOI: 10.1016/j.ejogrb.2019.03.018

Abstract

Thrombotic Microangiopathies during pregnancy and puerperium are very rare and, if undiagnosed, can be lifethreating. Pregnancy and postpartum can represent a trigger in predisposed patients. Therefore, obstetricians are usually the first to observe clinical symptoms and laboratory abnormalities suggestive of Thrombotic Microangiopathies. The aim of this review is to briefly describe the obstetrical and perinatal outcome of these entities and highlight the clues for a correct diagnosis of pregnancy-related Thrombotic Microangiopathies.

Keywords: Maternal and neonatal outcome; Pregnancy; Thrombotic microangiopathies.

Publication types

Review

MeSH terms

Diagnosis, Differential
Female
HELLP Syndrome / diagnosis
Humans
Pregnancy
Pregnancy Complications, Hematologic / diagnosis*
Thrombotic Microangiopathies / diagnosis*