Can the Microbiome Deliver? A Proof-of-Concept Engineered E. coli PKU Therapeutic

Christopher J Alteri

doi:10.1016/j.chom.2019.03.015

Can the Microbiome Deliver? A Proof-of-Concept Engineered E. coli PKU Therapeutic

Cell Host Microbe. 2019 Apr 10;25(4):473-474. doi: 10.1016/j.chom.2019.03.015.

Author

Christopher J Alteri¹

Affiliation

¹ Department of Natural Sciences, University of Michigan Dearborn, Dearborn, MI 48128, USA. Electronic address: alteri@umich.edu.

PMID: 30974078
DOI: 10.1016/j.chom.2019.03.015

Abstract

Phenylketonuria (PKU) is a rare genetic disorder that causes phenylalanine toxicity in the brain. Two studies, Crook et al. (2019), in this issue of Cell Host & Microbe, and Isabella et al. (2018), employ synthetic biology to develop a live bacterial therapeutic to treat PKU and potentially other metabolic diseases.

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MeSH terms

Brain
Escherichia coli
Humans
Microbiota*
Phenylalanine
Phenylketonurias*

Substances

Phenylalanine