Inflammation and Its Role in Regeneration and Repair

Circ Res. 2019 Apr 12;124(8):1166-1168. doi: 10.1161/CIRCRESAHA.118.314669.

Abstract

Inflammation plays an important role in tissue repair and regeneration. Recent work reveals that inflammatory signaling increases DNA accessibility so as to promote phenotypic fluidity in the response to injury.

Keywords: cardiovascular disease; endothelium; immunity; inflammation; regeneration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Anti-Inflammatory Agents / adverse effects*
  • B-Lymphocytes / physiology
  • Cell Plasticity
  • Cell Transdifferentiation / drug effects
  • Epigenesis, Genetic
  • Fibroblasts / metabolism
  • Glycolysis
  • Humans
  • Immunity, Innate
  • Inflammation Mediators / metabolism*
  • Inflammation* / immunology
  • Inflammation* / metabolism
  • Inflammation* / physiopathology
  • Nitric Oxide Synthase Type II / genetics
  • Nitric Oxide Synthase Type II / metabolism
  • Oxidative Phosphorylation
  • Regeneration / drug effects
  • Regeneration / immunology
  • Regeneration / physiology*
  • T-Lymphocytes, Cytotoxic / physiology
  • Wound Healing / drug effects
  • Wound Healing / immunology
  • Wound Healing / physiology

Substances

  • Anti-Inflammatory Agents
  • Inflammation Mediators
  • NOS2 protein, human
  • Nitric Oxide Synthase Type II