Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors

ACS Comb Sci. 2019 May 13;21(5):417-424. doi: 10.1021/acscombsci.9b00031. Epub 2019 Apr 19.

Abstract

Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of poly(methyl methacrylate- co-2-(dimethylamino) ethyl acrylate) (PA101), which allowed, via dip coating, the attachment of fluorescent pH sensors onto the tips of optical fibers, resulting in robust, rapid, and reproducible sensing of physiological pHs.

Keywords: high-throughput screening; optical fiber; pH sensor; polymer microarray.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coordination Complexes / chemistry
  • Fluoresceins / chemistry
  • Fluorescent Dyes / chemistry
  • High-Throughput Screening Assays
  • Microarray Analysis
  • Optical Fibers*
  • Palladium / chemistry
  • Polymethyl Methacrylate / chemistry*
  • Spectrometry, Fluorescence

Substances

  • Coordination Complexes
  • Fluoresceins
  • Fluorescent Dyes
  • 6-carboxyfluorescein
  • Palladium
  • Polymethyl Methacrylate