Four limonoids from the seeds extract of Sandoricum koetjape

Miranti B Bumi; Leny Heliawaty; Elvira Hermawati; Yana M Syah

doi:10.1007/s11418-019-01303-w

Four limonoids from the seeds extract of Sandoricum koetjape

J Nat Med. 2019 Jun;73(3):641-647. doi: 10.1007/s11418-019-01303-w. Epub 2019 Apr 10.

Authors

Miranti B Bumi¹, Leny Heliawaty², Elvira Hermawati¹, Yana M Syah³

Affiliations

¹ Organic Chemistry Division, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, Indonesia.
² Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Pakuan, Bogor, Indonesia.
³ Organic Chemistry Division, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, Indonesia. yana@chem.itb.ac.id.

PMID: 30972689
DOI: 10.1007/s11418-019-01303-w

Abstract

Three andirobin- and one trijugin-class limonoids, named koetjapins A-D (1-4), have been isolated from the seed extracts of Sandoricum koetjape. The structures of these compounds were determined by extensive NMR and mass spectral data, and the chemotaxonomic significance of these limonoids in the family Meliaceae is highlighted. Preliminary biological activity showed that only compound 4 has significant inhibitory activity against P-388 cells, while antibacterial tests showed that none of these compounds were active.

Keywords: Andirobin; Antibacterial; Cytotoxicity; Koetjapins A-D; Limonoid; Meliaceae; Sandoricum koetjape; Trijugin.

MeSH terms

Fruit / chemistry*
Limonins / pharmacology
Limonins / therapeutic use*
Molecular Structure
Seeds / chemistry*

Substances

Limonins