Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus

J Virol. 2019 Jun 14;93(13):e00238-19. doi: 10.1128/JVI.00238-19. Print 2019 Jul 1.

Abstract

Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects the majority of the world population. Under immunocompromised conditions, EBV can trigger human cancers of epithelial and lymphoid origin. The oncogenic potential of EBV is demonstrated by in vitro infection and transformation of quiescent B cells into lymphoblastoid cell lines (LCLs). These cell lines, along with primary infection using genetically engineered viral particles coupled with recent technological advancements, have elucidated the underlying mechanisms of EBV-induced B-cell lymphomagenesis.

Keywords: B-cell lymphomas; Epstein-Barr virus; lymphoblastoid cell lines; tumor virology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • B-Lymphocytes / virology*
  • Carcinogenesis*
  • Cell Line
  • Cell Transformation, Viral
  • Epstein-Barr Virus Infections / virology
  • Epstein-Barr Virus Nuclear Antigens / genetics
  • Gene Expression Regulation, Viral
  • Herpesvirus 4, Human / genetics*
  • Humans
  • Immunocompromised Host
  • Lymphoma, B-Cell / genetics
  • Lymphoma, B-Cell / virology*
  • Neoplasms
  • RNA, Untranslated
  • Virus Latency

Substances

  • Epstein-Barr Virus Nuclear Antigens
  • RNA, Untranslated