The Meniscus in Normal and Osteoarthritic Tissues: Facing the Structure Property Challenges and Current Treatment Trends

Annu Rev Biomed Eng. 2019 Jun 4:21:495-521. doi: 10.1146/annurev-bioeng-060418-052547. Epub 2019 Apr 8.

Abstract

The treatment of meniscus injuries has recently been facing a paradigm shift toward the field of tissue engineering, with the aim of regenerating damaged and diseased menisci as opposed to current treatment techniques. This review focuses on the structure and mechanics associated with the meniscus. The meniscus is defined in terms of its biological structure and composition. Biomechanics of the meniscus are discussed in detail, as an understanding of the mechanics is fundamental for the development of new meniscal treatment strategies. Key meniscal characteristics such as biological function, damage (tears), and disease are critically analyzed. The latest technologies behind meniscal repair and regeneration are assessed.

Keywords: biomechanics; cartilage; meniscus; osteoarthritis; repair.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomechanical Phenomena
  • Compressive Strength / physiology
  • Humans
  • Menisci, Tibial / anatomy & histology
  • Menisci, Tibial / physiology
  • Orthopedic Procedures / methods
  • Orthopedic Procedures / trends
  • Osteoarthritis, Knee / pathology*
  • Osteoarthritis, Knee / physiopathology
  • Osteoarthritis, Knee / surgery*
  • Regeneration / physiology
  • Tensile Strength / physiology
  • Tibial Meniscus Injuries / pathology*
  • Tibial Meniscus Injuries / physiopathology
  • Tibial Meniscus Injuries / surgery*
  • Tissue Engineering / methods*
  • Tissue Engineering / trends
  • Tissue Scaffolds