Abstract
A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2α-hydroxy-oleanolic acid (5), α-amyrin (6), and lupeol palmitate (7), respectively. Compounds 1 and 3 exhibited inhibitory effect against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 macrophage cell lines with IC50 values of 17.4 and 26.2 μM, respectively.
Keywords:
Sambucus javanica Blume.; javablumine A; triterpenes.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Lipopolysaccharides / pharmacology
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Mice
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Molecular Structure
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Nitric Oxide / metabolism
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Oleanolic Acid / analogs & derivatives
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Pentacyclic Triterpenes / isolation & purification
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Pentacyclic Triterpenes / pharmacology
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Plant Components, Aerial / chemistry
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RAW 264.7 Cells
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Sambucus / chemistry*
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
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Ursolic Acid
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lipopolysaccharides
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Pentacyclic Triterpenes
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Triterpenes
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alpha-amyrin
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Nitric Oxide
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pomolic acid
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Oleanolic Acid
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beta-amyrin