Abstract
Two new compounds, an abscisic acid-type sesquiterpene (1), and one asterric acid derivative (2), together with three known compounds (3-5) were isolated from mangrove endophytic fungus Pleosporales sp. SK7. The structures of these metabolites were determined by NMR, X-ray crystal diffraction, CD and HR-ESI-MS. All compounds were tested for their antibacterial, antioxidant and cytotoxic activities, among these compounds, 5 showed cytotoxicity against MDA-MB-435 cell with an IC50 of 25.96 ± 0.32 μM.
Keywords:
Mangrove fungus metabolism; Pleosporales sp.; antibacterial; antioxidant; cytotoxicity.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Ascomycota / chemistry
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Endophytes / metabolism*
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Fungi / metabolism*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Phenyl Ethers / isolation & purification
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Sesquiterpenes / isolation & purification
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Wetlands*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Antioxidants
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Phenyl Ethers
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Sesquiterpenes
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asterric acid