α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine

Sa Liu; Chunting Zhong; Weiwei Wang; Yongguang Jia; Lin Wang; Li Ren

doi:10.3390/polym10020190

α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine

Polymers (Basel). 2018 Feb 14;10(2):190. doi: 10.3390/polym10020190.

Authors

Sa Liu^{1

2}, Chunting Zhong^{3

4}, Weiwei Wang^{5

6}, Yongguang Jia^{7

8}, Lin Wang^{9

10}, Li Ren^{11

12}

Affiliations

¹ School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. sliu@scut.edu.cn.
² National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China. sliu@scut.edu.cn.
³ School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. msctzhong@mail.scut.edu.cn.
⁴ National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China. msctzhong@mail.scut.edu.cn.
⁵ School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. wei880719@163.com.
⁶ National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China. wei880719@163.com.
⁷ School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. ygjia@scut.edu.cn.
⁸ National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China. ygjia@scut.edu.cn.
⁹ School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. wanglin3@scut.edu.cn.
¹⁰ National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China. wanglin3@scut.edu.cn.
¹¹ School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. psliren@scut.edu.cn.
¹² National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China. psliren@scut.edu.cn.

Abstract

As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).

Keywords: antibacterial; mechanism; polyrotaxane; silver sulfadiazine.