Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

Ming Bi; Hui Han; Shujun Dong; Ying Zhang; Weiguo Xu; Bitao Zhu; Jingyun Wang; Yanmin Zhou; Jianxun Ding

doi:10.3390/polym10020109

Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

Polymers (Basel). 2018 Jan 24;10(2):109. doi: 10.3390/polym10020109.

Authors

Ming Bi¹, Hui Han², Shujun Dong³, Ying Zhang⁴, Weiguo Xu⁵, Bitao Zhu⁶, Jingyun Wang⁷, Yanmin Zhou⁸, Jianxun Ding⁹

Affiliations

¹ Department of General Dentistry, School and Hospital of Stomatology, Jilin University, Changchun 130021, China. biming11@mails.jlu.edu.cn.
² Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun 130021, China. hh198404@hotmail.com.
³ VIP Integrated Department, School and Hospital of Stomatology, Jilin University, Changchun 130021, China. dsj@jlu.edu.cn.
⁴ Department of Orthopedics, Zhongshan Hospital Affiliated to Xiamen University, Xiamin 361004, China. xmzhangying@163.com.
⁵ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. wgxu@ciac.ac.cn.
⁶ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. btzhu@ciac.ac.cn.
⁷ Department of General Dentistry, School and Hospital of Stomatology, Jilin University, Changchun 130021, China. jlccjingyun@sina.com.
⁸ Department of General Dentistry, School and Hospital of Stomatology, Jilin University, Changchun 130021, China. zhouym62@126.com.
⁹ Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jxding@ciac.ac.cn.

Abstract

The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances of scaffolds in bone tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results indicated that the mechanical strength and hydrophilicity of the PLGA/HA scaffold were clearly improved and conducive to cell adhesion and proliferation. The collagen-coated scaffold with DGEA significantly promoted the repair of skull defect. These findings indicated that a combination of collagen coating and DGEA improved scaffold properties for bone regeneration, thereby providing a new potential strategy for scaffold design.

Keywords: bioactive peptide; collagen coating; porous scaffold; skull defect repair; tissue engineering.