Ovarian Mucinous Carcinoma with Mural Carcinosarcomatous Components in a Prepubertal Girl

Kayo Suzuki; Hiroki Imada; Akihiro Igarashi; Yoko Saitou; Satoshi Takakura

doi:10.1016/j.jpag.2019.04.005

Ovarian Mucinous Carcinoma with Mural Carcinosarcomatous Components in a Prepubertal Girl

J Pediatr Adolesc Gynecol. 2019 Aug;32(4):436-439. doi: 10.1016/j.jpag.2019.04.005. Epub 2019 Apr 6.

Authors

Kayo Suzuki¹, Hiroki Imada², Akihiro Igarashi³, Yoko Saitou⁴, Satoshi Takakura⁴

Affiliations

¹ Department of Obstetrics and Gynecology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan. Electronic address: kayo0903@live.jp.
² Department of Pathology, Dokkyo Medical University, Saitama Medical Center, Koshigaya, Japan.
³ Department of Pediatric Surgery, Dokkyo Medical University, Saitama Medical Center, Koshigaya, Japan.
⁴ Department of Obstetrics and Gynecology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.

PMID: 30965111
DOI: 10.1016/j.jpag.2019.04.005

Abstract

Background: Epithelial ovarian cancer development before menarche is extremely rare.

Case: We report a prepubertal girl who developed ovarian mucinous carcinoma with mural carcinosarcomatous components.

Summary and conclusion: Magnetic resonance imaging showed a polycystic mass with solid components. The left adnexa was removed. Histological analysis revealed a mucinous tumor with mural carcinosarcomatous components. Three weeks later, ascites and peritoneal metastasis were detected. The patient received a combination therapy of paclitaxel with carboplatin. After 4 chemotherapy cycles the right adnexa, uterus, partial omentum, and pelvic peritoneum were removed. Four additional paclitaxel/carboplatin therapy cycles were administered. She remains free from recurrence after 29 months. To our knowledge, this is the first report of ovarian mucinous carcinoma with mural carcinosarcomatous components in a prepubertal girl.

Keywords: Carcinosarcomatous components; Ovarian mucinous carcinoma; Prepubertal girl.

MeSH terms

Adenocarcinoma, Mucinous / diagnostic imaging
Adenocarcinoma, Mucinous / pathology*
Adenocarcinoma, Mucinous / therapy
Adolescent
Antineoplastic Agents / therapeutic use
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Carboplatin / therapeutic use
Carcinoma, Ovarian Epithelial / diagnostic imaging
Carcinoma, Ovarian Epithelial / pathology*
Combined Modality Therapy
Female
Humans
Magnetic Resonance Imaging
Ovarian Neoplasms / diagnostic imaging
Ovarian Neoplasms / pathology*
Ovarian Neoplasms / therapy
Paclitaxel / therapeutic use

Substances

Antineoplastic Agents
Carboplatin
Paclitaxel