Relax, Kinetochores Are Exquisitely Sensitive to Tension

Joshua D Larson; Charles L Asbury

doi:10.1016/j.devcel.2019.03.019

Relax, Kinetochores Are Exquisitely Sensitive to Tension

Dev Cell. 2019 Apr 8;49(1):5-7. doi: 10.1016/j.devcel.2019.03.019.

Authors

Joshua D Larson¹, Charles L Asbury²

Affiliations

¹ Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA.
² Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address: casbury@uw.edu.

PMID: 30965035
DOI: 10.1016/j.devcel.2019.03.019

Abstract

By estimating the absolute levels of tension at kinetochores in dividing yeast cells and relating these measurements to kinetochore detachment probability, Mukherjee et al. (2019) quantify in this issue of Developmental Cell the force sensitivity of the mitotic error correction system.

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MeSH terms

Kinetochores*
Metaphase
Microtubules
Mitosis*
Spindle Apparatus