A Concise Asymmetric Total Synthesis of (+)-Epilupinine

Org Lett. 2019 Apr 19;21(8):2620-2624. doi: 10.1021/acs.orglett.9b00607. Epub 2019 Apr 9.

Abstract

Asymmetric total synthesis of (+)-epilupinine was achieved in just three steps using only commercially available common reagents. The total synthesis involved alkylations of N-nosylamide, ozone oxidation, and sequential reactions of the removal of the nosyl group, intramolecular dehydrative condensation, intramolecular Mannich reaction catalyzed by l-proline, and a reduction.

Publication types

  • Research Support, Non-U.S. Gov't