Construction and Analysis of miRNA Regulatory Networks

Antonella Mensi; Vincenzo Bonnici; Simone Caligola; Rosalba Giugno

doi:10.1007/978-1-4939-9207-2_9

Construction and Analysis of miRNA Regulatory Networks

Methods Mol Biol. 2019:1970:121-167. doi: 10.1007/978-1-4939-9207-2_9.

Authors

Antonella Mensi¹, Vincenzo Bonnici¹, Simone Caligola¹, Rosalba Giugno²

Affiliations

¹ Department of Computer Science, University of Verona, Verona, Italy.
² Department of Computer Science, University of Verona, Verona, Italy. rosalba.giugno@univr.it.

PMID: 30963492
DOI: 10.1007/978-1-4939-9207-2_9

Abstract

This chapter is devoted to illustrate the usage of state-of-the-art methodologies for miRNA regulatory network construction and analysis. Advantages in understanding the role of miRNAs in regulating gene expression are increasing the possibility of developing targeted therapies and drugs. This new possibility can be exploited by gaining new knowledge through analyzing interactions between a specific miRNA and a targeted gene.

Keywords: Enrichment analysis; Expression data; Network analysis; miRNA networks; miRNA targets.

MeSH terms

Computational Biology / methods*
Gene Expression Profiling / methods*
Gene Expression Regulation
Gene Regulatory Networks*
Humans
MicroRNAs / genetics*
MicroRNAs / metabolism
RNA, Messenger / genetics*
RNA, Messenger / metabolism
Software*

Substances

MicroRNAs
RNA, Messenger