Carbapenem-Susceptible OXA-23-Producing Proteus mirabilis in the French Community

Antimicrob Agents Chemother. 2019 May 24;63(6):e00191-19. doi: 10.1128/AAC.00191-19. Print 2019 Jun.

Abstract

Nineteen Proteus mirabilis isolates producing the carbapenemase OXA-23 were recovered over a 2-year period in 19 French hospitalized patients, of whom 12 had community onset infections. The isolates exhibited a slightly reduced susceptibility to carbapenems. Whole-genome analysis revealed that all 19 isolates formed a cluster compared to 149 other P. mirabilis isolates. Because of its susceptibility to carbapenems, this clone may be misidentified as a penicillinase producer while it constitutes a reservoir of the OXA-23-encoding gene in the community.

Keywords: OXA-23; Proteus mirabilis; carbapenemase; clonality; spread.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Carbapenems / pharmacology*
  • France / epidemiology
  • Humans
  • Microbial Sensitivity Tests
  • Proteus Infections / epidemiology
  • Proteus Infections / microbiology*
  • Proteus mirabilis / drug effects
  • Proteus mirabilis / enzymology*
  • Proteus mirabilis / genetics
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • beta-lactamase OXA-23
  • beta-Lactamases