Cutaneous and Renal Glomerular Vasculopathy: What Do We Know so Far?

Rosanne E Jepson; Jacqueline M Cardwell; Stefano Cortellini; Laura Holm; Kim Stevens; David Walker

doi:10.1016/j.cvsm.2019.02.010

Cutaneous and Renal Glomerular Vasculopathy: What Do We Know so Far?

Vet Clin North Am Small Anim Pract. 2019 Jul;49(4):745-762. doi: 10.1016/j.cvsm.2019.02.010. Epub 2019 Apr 5.

Authors

Rosanne E Jepson¹, Jacqueline M Cardwell², Stefano Cortellini³, Laura Holm⁴, Kim Stevens², David Walker⁴

Affiliations

¹ Department of Clinical Science and Services, Royal Veterinary College, Queen Mother Hospital for Animals, Hawkshead Lane, North Mymms, Herts, London AL9 7TA, UK. Electronic address: rjepson@rvc.ac.uk.
² Department of Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, London AL9 7TA, UK.
³ Department of Clinical Science and Services, Royal Veterinary College, Queen Mother Hospital for Animals, Hawkshead Lane, North Mymms, Herts, London AL9 7TA, UK.
⁴ Anderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester SO21 2LL, UK.

PMID: 30961997
DOI: 10.1016/j.cvsm.2019.02.010

Abstract

Cutaneous renal glomerular vasculopathy (CRGV), colloquially named "Alabama rot," is an emerging condition in the United Kingdom, previously reported from the United States and Germany. The cause of CRGV is not yet determined; no definitive link to an infectious agent has been made. Dogs diagnosed with CRGV initially develop cutaneous lesions, and a proportion of these dogs go on to manifest acute kidney injury, which may result in oligoanuric acute renal failure. Antemortem diagnosis is challenging given the lack of a specific diagnostic test, and confirmation of CRGV is therefore currently dependent on identification of thrombotic microangiopathy on renal histopathology.

Keywords: Acute kidney injury; Alabama rot; CRGV; Skin lesion; Thrombotic microangiopathy.

Publication types

Review

MeSH terms

Animals
Dog Diseases / mortality
Dog Diseases / pathology*
Dogs
Kidney Diseases / pathology
Kidney Diseases / veterinary*
Kidney Glomerulus / pathology
Skin Ulcer / pathology
Skin Ulcer / veterinary*
Vascular Diseases / pathology
Vascular Diseases / veterinary*