New Furanocembranoids from Briareum violaceum

Pin-Chang Huang; Wen-Sou Lin; Bo-Rong Peng; Yu-Chia Chang; Lee-Shing Fang; Guo-Qiang Li; Tsong-Long Hwang; Zhi-Hong Wen; Ping-Jyun Sung

doi:10.3390/md17040214

New Furanocembranoids from Briareum violaceum

Mar Drugs. 2019 Apr 5;17(4):214. doi: 10.3390/md17040214.

Authors

Pin-Chang Huang^{1

2}, Wen-Sou Lin^{3

4}, Bo-Rong Peng⁵, Yu-Chia Chang⁶, Lee-Shing Fang^{7

8}, Guo-Qiang Li^{9

10}, Tsong-Long Hwang^{11

12

13

14}, Zhi-Hong Wen¹⁵, Ping-Jyun Sung^{16

17

18

19

20

21}

Affiliations

¹ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan. foter25632@gmail.com.
² Department of Planning and Research, National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan. foter25632@gmail.com.
³ Department of Neurology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan. linvincent1009@gmail.com.
⁴ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. linvincent1009@gmail.com.
⁵ Department of Planning and Research, National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan. pengpojung@gmail.com.
⁶ Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan. jay0404@gmail.com.
⁷ Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 83347, Taiwan. lsfang@csu.edu.tw.
⁸ Super Micro Mass Research and Technology Center, Cheng Shiu University, Kaohsiung 83347, Taiwan. lsfang@csu.edu.tw.
⁹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266033, China. liguoqiang@ouc.edu.cn.
¹⁰ Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao 266235, China. liguoqiang@ouc.edu.cn.
¹¹ Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan. htl@mail.cgu.edu.tw.
¹² Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. htl@mail.cgu.edu.tw.
¹³ Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan. htl@mail.cgu.edu.tw.
¹⁴ Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan. htl@mail.cgu.edu.tw.
¹⁵ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. wzh@mail.nsysu.edu.tw.
¹⁶ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan. pjsung@nmmba.gov.tw.
¹⁷ Department of Planning and Research, National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan. pjsung@nmmba.gov.tw.
¹⁸ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. pjsung@nmmba.gov.tw.
¹⁹ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. pjsung@nmmba.gov.tw.
²⁰ Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. pjsung@nmmba.gov.tw.
²¹ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan. pjsung@nmmba.gov.tw.

Abstract

Three new furanocembranoids-briaviodiol F (1) and briaviotriols A (2) and B (3)-along with a known analogue, briaviodiol A (4), were obtained from a cultured-type octocoral Briareum violaceum. The structures of cembranoids 1⁻3 were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds 2 and 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.7, a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.

Keywords: Briareum violaceum; anti-inflammatory; briaviodiol; briaviotriol; iNOS.

MeSH terms

Animals
Anthozoa / chemistry*
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Mice
Models, Molecular
Molecular Structure
Nitric Oxide Synthase Type II / antagonists & inhibitors*
RAW 264.7 Cells

Substances

Anti-Inflammatory Agents
Diterpenes
Nitric Oxide Synthase Type II
Nos2 protein, mouse