Aim: We aim to study the mechanism of reflex seizure triggering in close link with the system-epilepsy concept.
Method: We use data and theories presented in the literature and scrutinize a few illustrative cases.
Conclusions: The prerequisite of seizure triggering is an epilepsy-prone brain network. When it is activated, it may produce seizures manifesting the function(s) of the same system. Beyond classical reflex seizures triggered by sensory-motor stimuli, we extend the reflex-epilepsy concept to seizures induced by the normal activation of epilepsy-prone systems e.g. praxis-induced seizures and those of sleep/wake system epilepsies elicited by falling asleep (absences) or arousals from NREM sleep (seizures of genetic frontal lobe epilepsy). We suggest that normal functioning of epilepsy-prone systems may trigger seizures in epilepsies in general.
Keywords: Reflex epilepsy; Reflex seizure; Sleep related epilepsy; System epilepsy.
Copyright © 2019. Published by Elsevier Ltd.