Intracellular and Cellular Detection by SERS-Active Plasmonic Nanostructures

Chembiochem. 2019 Oct 1;20(19):2432-2441. doi: 10.1002/cbic.201900191. Epub 2019 Jul 2.

Abstract

Surface-enhanced Raman scattering (SERS), with greatly amplified fingerprint spectra, holds great promise in biochemical and biomedical research. In particular, the possibility of exciting a library of SERS probes and differentially detecting them simultaneously has stimulated widespread interest in multiplexed biodetection. Herein, recent progress in developing SERS-active plasmonic nanostructures for cellular and intracellular detection is summarized. The development of nanosensors with tailored plasmonic and multifunctional properties for profiling molecular and pathological processes is highlighted. Future challenges towards the routine use of SERS technology in quantitative bioanalysis and clinical diagnostics are further discussed.

Keywords: Raman spectroscopy; biosensors; imaging agents; nanostructures; surface plasmon resonance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gold / chemistry
  • Humans
  • Metal Nanoparticles / administration & dosage*
  • Metal Nanoparticles / chemistry
  • Multimodal Imaging / methods*
  • Nanostructures / chemistry*
  • Neoplasms / diagnostic imaging
  • Neoplasms / pathology*
  • Spectrum Analysis, Raman / instrumentation*
  • Spectrum Analysis, Raman / methods*

Substances

  • Gold