The effective field theory of quantum gravity generically predicts non-locality to be present in the effective action, which results from the low-energy propagation of gravitons and massless matter. Working to second order in gravitational curvature, we reconsider the effects of quantum gravity on the gravitational radiation emitted from a binary system. In particular, we calculate for the first time the leading order quantum gravitational correction to the classical quadrupole radiation formula which appears at second order in Newton's constant.