This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral infections present a potential risk for oral-oral as well as fecal-oral poliovirus transmission during transition to a poliovirus 2-free world.
Keywords: Contact isolation; Droplet isolation; Oropharyngeal mucosa; Primary immune deficiency (PID); Stools; Type 2 vaccine-derived poliovirus (iVDPV2).
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