Counting Calories: The Cost of Inflammation

Andrew Wang; Ruslan Medzhitov

doi:10.1016/j.cell.2019.03.022

Counting Calories: The Cost of Inflammation

Cell. 2019 Apr 4;177(2):223-224. doi: 10.1016/j.cell.2019.03.022.

Authors

Andrew Wang¹, Ruslan Medzhitov²

Affiliations

¹ Department of Medicine (Rheumatology), Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: andrew.wang@yale.edu.
² Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: ruslan.medzhitov@yale.edu.

PMID: 30951664
DOI: 10.1016/j.cell.2019.03.022

Abstract

A relationship between thermoregulation, metabolism, and the host response to infections has long been appreciated. In this study, Ganeshan and colleagues discover that the immune system regulates body temperature as a strategy to regulate metabolic rate, which in turn promotes tolerance to inflammatory damage.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Body Temperature
Body Temperature Regulation*
Humans
Immune Tolerance
Inflammation*

Abstract

Publication types

MeSH terms

Grants and funding