Toward a Universal Solution: Editing Compatibility into Pluripotent Stem Cells

Alan Trounson; Nicholas R Boyd; Richard L Boyd

doi:10.1016/j.stem.2019.03.003

Toward a Universal Solution: Editing Compatibility into Pluripotent Stem Cells

Cell Stem Cell. 2019 Apr 4;24(4):508-510. doi: 10.1016/j.stem.2019.03.003.

Authors

Alan Trounson¹, Nicholas R Boyd², Richard L Boyd²

Affiliations

¹ Hudson Institute of Medical Research, Monash University, Clayton, VIC, Australia; Cartherics Pty. Ltd., Clayton, VIC, Australia. Electronic address: alan.trounson@hudson.org.au.
² Hudson Institute of Medical Research, Monash University, Clayton, VIC, Australia; Cartherics Pty. Ltd., Clayton, VIC, Australia.

PMID: 30951658
DOI: 10.1016/j.stem.2019.03.003

Abstract

In this issue of Cell Stem Cell, Xu et al. (2019) demonstrate that editing iPSCs' major histocompatibility antigens may potentially provide a small set of universally compatible stem cell lines for therapies. However, these modifications may result in patient minor histocompatibility responses and deficiencies in their T cell response repertoire to infection and cancer.

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MeSH terms

CRISPR-Cas Systems
Cell Line
Clustered Regularly Interspaced Short Palindromic Repeats
Humans
Induced Pluripotent Stem Cells*
Pluripotent Stem Cells*