Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression

F Ceia; A Silva-Pinto; A C Carvalho; C Piñeiro; J Soares; R Serrão; A Sarmento

doi:10.1093/ofid/ofz063

Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression

Open Forum Infect Dis. 2019 Feb 12;6(4):ofz063. doi: 10.1093/ofid/ofz063. eCollection 2019 Apr.

Authors

F Ceia^{1

2}, A Silva-Pinto^{1

2}, A C Carvalho^{1

3}, C Piñeiro^{1

2}, J Soares¹, R Serrão^{1

2}, A Sarmento^{1

2

4}

Affiliations

¹ Infectious Diseases Department, Centro Hospitalar São João, Porto, University of Porto, Portugal.
² Faculty of Medicine, University of Porto, University of Porto, Portugal.
³ Instituto de Saúde Pública da Universidade do Porto, University of Porto, Portugal.
⁴ Nephrology and Infectious Diseases R&D Group, Health Investigation and Innovation Institute, University of Porto, Portugal.

Abstract

Dual human immunodeficiency virus (HIV) 1 and HIV-2 superinfections are rare but challenging. A HIV-1-infected patient receiving effective antiretroviral therapy was investigated for a severe CD4⁺ cell count decline. HIV-2 superinfection was diagnosed and genotypic test revealed mutations conferring resistance to most drug class, limiting options for treatment.

Keywords: HIV-1; HIV-2; human immunodeficiency virus; immunosuppression; pre-exposure prophylaxis.