A cobalt oxide nanocubes interleaved reduced graphene oxide nanocomposite modified glassy carbon electrode for amperometric detection of serotonin

Muhammad Mehmood Shahid; Perumal Rameshkumar; Arshid Numan; Syed Shahabuddin; Mahdi Alizadeh; Poi Sim Khiew; Wee Siong Chiu

doi:10.1016/j.msec.2019.02.107

A cobalt oxide nanocubes interleaved reduced graphene oxide nanocomposite modified glassy carbon electrode for amperometric detection of serotonin

Mater Sci Eng C Mater Biol Appl. 2019 Jul:100:388-395. doi: 10.1016/j.msec.2019.02.107. Epub 2019 Feb 28.

Authors

Muhammad Mehmood Shahid¹, Perumal Rameshkumar², Arshid Numan³, Syed Shahabuddin⁴, Mahdi Alizadeh⁵, Poi Sim Khiew⁶, Wee Siong Chiu⁷

Affiliations

¹ Higher Institution Centre of Excellence (HICoE), UM Power Energy Dedicated Advanced Centre (UMPEDAC), Level 4, Wisma R&D University of Malaya, Jalan Pantai Baharu, 59990 Kuala Lumpur, Malaysia. Electronic address: shahid@um.edu.my.
² Department of Chemistry, Kalasalingam University (Kalasalingam Academy of Research and Education), Krishnankoil 626 126, Tamil Nadu, India.
³ School of Science and Technology, Sunway University, No. 5, Jalan University, Bandar Sunway, 47500 Subang Jaya, Selangor.
⁴ Research Centre for Nano-Materials and Energy Technology (RCNMET), School of Science and Technology, Sunway University, Malaysia.
⁵ Higher Institution Centre of Excellence (HICoE), UM Power Energy Dedicated Advanced Centre (UMPEDAC), Level 4, Wisma R&D University of Malaya, Jalan Pantai Baharu, 59990 Kuala Lumpur, Malaysia; Laser-Plasma Research Institute, Shahid Beheshti University, G.C, Evin, Tehran 19839, Iran.
⁶ Center of Nanotechnology and Advanced Materials, Faculty of Engineering, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.
⁷ Low Dimensional Materials Research Centre, Department of Physics, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

PMID: 30948075
DOI: 10.1016/j.msec.2019.02.107

Abstract

Cobalt oxide nanocubes incorporated with reduced graphene oxide (rGO-Co₃O₄) was prepared by using simple one-step hydrothermal route. Crystallinity and structural characteristics of the nanocomposite were analyzed and confirmed using X-ray diffraction (XRD) and Raman analysis, respectively. The cubical shape of the Co₃O₄ nanostructures and the distribution of Co₃O₄ nanocubes on the surface of rGO sheets were identified through field emission scanning electron microscopy (FESEM) and energy dispersive X-ray (EDX) mapping analysis, respectively. Raman spectra depicted the presence of D and G bands for GO and rGO with different I_D/I_G values and thus confirmed the reduction of GO into rGO. The electrochemical study reflects that the rGO-Co₃O₄ nanocomposite shows good electrocatalytic activity in oxidation of depression biomarker serotonin (5-HT) in phosphate buffer (pH 7.2). The detection of 5-HT was carried out by using rGO-Co₃O₄ nanocomposite modified glassy carbon electrode under dynamic condition using amperometry technique with a linear range of 1-10 μM. The limit of detection and limit of quantification were calculated and found to be 1.128 and 3.760 μM, respectively with a sensitivity value of 0.133 μΑ·μM^-1. The sensor showed selectivity in the presence of different interferent species such as ascorbic acid, dopamine and uric acid.

Keywords: Cobalt oxide nanocubes; Electrochemical sensor; Hydrothermal synthesis; Reduced graphene oxide; Serotonin.

MeSH terms

Carbon / chemistry*
Catalysis
Cobalt / chemistry*
Electrochemical Techniques / methods*
Electrodes
Glass / chemistry*
Graphite / chemistry*
Nanocomposites / chemistry*
Nanocomposites / ultrastructure
Oxidation-Reduction
Oxides / chemistry*
Serotonin / analysis*
Spectrum Analysis, Raman
X-Ray Diffraction

Substances

Oxides
graphene oxide
Serotonin
Cobalt
Carbon
Graphite
cobalt oxide