The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer

Jiayuan Qu; Mohammad Amjad Kamal; Chengfu Yuan

doi:10.2174/1381612825666190404122154

The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer

Curr Pharm Des. 2019;25(8):856-861. doi: 10.2174/1381612825666190404122154.

Authors

Jiayuan Qu¹, Mohammad Amjad Kamal^{2

3}, Chengfu Yuan¹

Affiliations

¹ Department of Biochemistry, China Three Gorges University, Yichang 443002, China.
² King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah, 21589, Saudi Arabia.
³ Novel Global Community Educational Foundation, Austrália.

PMID: 30947657
DOI: 10.2174/1381612825666190404122154

Abstract

Background: Ovarian cancer is the most malignant tumor in gynecological tumors, with low five-year survival rate. The main reasons are diagnosis at advanced stages (the early symptoms are uncharacteristic, and most are diagnosedlate.), relapse, and resistance to existing chemotherapy drugs.

Methods: Search strategy was performed in the following steps. Firstly, LncRNA related to ovarian cancer was retrieved by using the LncRNA Disease database, and articles were searched by searching keywords: ovarian cancer, drug resistance, and LncRNA retrieved from the LncRNA Disease database.

Results/conclusion: With the development of the study on drug resistance of ovarian cancer, the role of LncRNAs as sensitive biomarker and therapeutic target has emerged, providing a direction for precision medicine of ovarian cancer resistance.

Keywords: LncRNA; Ovarian cancer; chemoresistance; drug resistance; gynecological tumors; long non-coding RNA..

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers, Tumor / genetics
Drug Resistance, Neoplasm*
Female
Humans
Neoplasm Recurrence, Local
Ovarian Neoplasms / drug therapy*
Ovarian Neoplasms / genetics*
RNA, Long Noncoding / genetics*

Substances

Biomarkers, Tumor
RNA, Long Noncoding