Fatty Acid Desaturation Gets a NAD+ Reputation

Andrew J Lutkewitte; Shawn C Burgess; Brian N Finck

doi:10.1016/j.cmet.2019.03.007

Fatty Acid Desaturation Gets a NAD⁺ Reputation

Cell Metab. 2019 Apr 2;29(4):790-792. doi: 10.1016/j.cmet.2019.03.007.

Authors

Andrew J Lutkewitte¹, Shawn C Burgess², Brian N Finck³

Affiliations

¹ Division of Geriatrics and Nutritional Sciences, Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
² Center for Human Nutrition, Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
³ Division of Geriatrics and Nutritional Sciences, Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: bfinck@wustl.edu.

Abstract

delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids. In this issue, Kim et al. (2019) show that production of NAD⁺ by this desaturase reaction is an adaptive response to NAD⁺ depletion that may regulate cellular REDOX status.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Fatty Acids, Unsaturated*
NAD*
Oxidoreductases

Substances

Fatty Acids, Unsaturated
NAD
Oxidoreductases

Abstract

Publication types

MeSH terms

Substances

Grants and funding