Abstract
A lysosome-targeting and polarity-specific fluorescent probe CPM has been rationally designed for cancer diagnosis and imaging. We have successfully shown that lysosome polarity may serve as an ubiquitious marker for cancer detection. The potential of CPM for cancer diagnosis has also been demonstrated at the levels of live cells, organs, whole animal, and clinical patient tissue samples.
MeSH terms
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Animals
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Cell Line, Tumor
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Cell Survival / drug effects
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Coumarins / chemical synthesis
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Coumarins / chemistry*
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Coumarins / toxicity
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Fluorescence
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / toxicity
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Humans
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Lysosomes / metabolism*
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Mice
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Microscopy, Confocal / methods
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Microscopy, Fluorescence / methods
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Neoplasms / diagnosis*
Substances
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Coumarins
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Fluorescent Dyes