Caspases (cysteine-aspartic proteases) represent a family of enzymes that modify several functions crucial for cell homeostasis such as inflammation and apoptosis. According to their implication in the apoptotic pathways, caspases are characterized as initiators and executioners, respectively. In the first group have been inserted caspase-2,-8,-9, and -10, whereas caspase-3,-6, and-7 belong to the second category. All of these normal actions of the caspase complex that induce apoptosis are altered in carcinoma progression and establishment. In cancer tissues, programmed cell death is inhibited due to a deregulation in expression of apo- and anti-apoptotic proteins. This genetic imbalance drives the cancer cell to immortalization which reflects the aberrant tissue proliferation. For this reason, caspases and the other apoptotic molecules are considered as important targets for specific targeted therapeutic strategies for enhancing the apoptotic levels inside the malignant tumor cells cores. In the current review we explored the role of caspases deregulation in laryngeal squamous cell carcinoma (LSCC). In malignancies -including LSCC- its deregulation leads the cells to immortalization due to apoptosis inhibition and telomerase overexpression. Caspase-dependent apoptotic rates are decreased in LSCC. For this reason, caspases are considered a very promising target for applying targeted therapeutic strategies in order to enhance apoptosis in the corresponding patients suffering of LSCC.