Radical Umpolung: Efficient Options for the Synthesis of 1,4-Dicarbonyl Compounds

Abstract

Radical developments: Photochemical/secondary amine dual catalysis has proven to be an efficient strategy for radical umpolung reactions. Two new processes provide an elegant solution to a long-standing chemoselectivity problem for the synthesis of 1,4-dicarbonyl compounds.

Keywords: Stetter reaction; dicarbonyl compounds; organocatalysis; photocatalysis; umpolung.