Variations in the PBEF1 gene are associated with body mass index: A population-based study in northern China

Jiesheng Rong; Minjie Chu; Baifen Xing; Lin Zhu; Shengyu Wang; Tianzun Tao; Yashuang Zhao; Liying Jiang

doi:10.1016/j.mgene.2015.08.004

Variations in the PBEF1 gene are associated with body mass index: A population-based study in northern China

Meta Gene. 2015 Sep 21:6:65-68. doi: 10.1016/j.mgene.2015.08.004. eCollection 2015 Dec.

Authors

Jiesheng Rong¹, Minjie Chu², Baifen Xing³, Lin Zhu⁴, Shengyu Wang¹, Tianzun Tao¹, Yashuang Zhao⁴, Liying Jiang²

Affiliations

¹ Second Department of Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, PR China.
² Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu Province, PR China.
³ Hongqi Community Health Service Center, Xiangfang District, Harbin, Heilongjiang Province, PR China.
⁴ Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, PR China.

Abstract

Objective: PBEF1 and its polymorphisms may be important in the physiopathology of obesity. We hypothesized that polymorphisms in PBEF1 gene may modify body mass index (BMI).

Methods: Thus, we systematically screened 4 tagging polymorphisms (rs4730153, rs2058540, rs3801267 and rs16872158) in PBEF1 gene and evaluated the association between the genetic variants and BMI in a population-based study including 442 subjects in northern China.

Results: We found that the SNP rs3801267 was significantly associated with decreased BMI (P = 0.026 in additive model), while the other 2 SNPs (rs4730153 and rs16872158) showed a borderline significant association with decreased BMI (P = 0.068 and 0.060 in additive models). Combined analysis of these 3 SNPs showed a significant allele-dosage association between the number of variant alleles and decreased BMI (P _trend = 0.007).

Conclusions: These findings indicate that genetic variants in PBEF1 gene may modify individual BMI in the Chinese population.

Keywords: BMI; PBEF1; SNP; Susceptibility.