Infections with DNA Viruses, Adenovirus, Polyomaviruses, and Parvovirus B19 in Hematopoietic Stem Cell Transplant Recipients and Patients with Hematologic Malignancies

Infect Dis Clin North Am. 2019 Jun;33(2):501-521. doi: 10.1016/j.idc.2019.02.005. Epub 2019 Mar 30.

Abstract

Infections due to adenovirus, polyomaviruses (BK and JC viruses), and parvovirus B19 may not be as common as infections due to other DNA viruses, such as cytomegalovirus in patients with hematological malignancies and the recipients of hematopoietic stem cell transplantation. However, these infections may result in life-threatening diseases that significantly impact patients' recovery, morbidity, and mortality. Treating physicians should be aware of the diseases associated with these viruses, the patient populations at increased risk for complications due to these infections, and the available diagnostic and therapeutic approaches.

Keywords: Adenovirus; BK virus; Hematologic malignancies; Hematopoietic stem cell transplant; JC virus; Parvovirus B19; Polyomavirus; Therapy.

Publication types

  • Review

MeSH terms

  • Adenoviridae Infections / complications
  • Antiviral Agents / therapeutic use
  • DNA Virus Infections / complications
  • DNA Virus Infections / drug therapy*
  • DNA Virus Infections / mortality
  • Erythema Infectiosum / complications
  • Hematologic Neoplasms / complications
  • Hematologic Neoplasms / virology*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Polyomavirus Infections / complications
  • Risk Factors
  • Viremia / drug therapy

Substances

  • Antiviral Agents