Early detection of elevated lactate levels in a mitochondrial disease model using chemical exchange saturation transfer (CEST) and magnetic resonance spectroscopy (MRS) with 7T MR imaging

Affiliations

• ¹ Division of Health Sciences, Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Osaka, 560-0871, Japan. saito@sahs.med.osaka-u.ac.jp.
• ² Department of Biomedical Imaging, National Cardiovascular and Cerebral Research Center, Suita, Osaka, 565-8565, Japan. saito@sahs.med.osaka-u.ac.jp.
• ³ Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
• ⁴ Department of Biomedical Imaging, National Cardiovascular and Cerebral Research Center, Suita, Osaka, 565-8565, Japan.
• ⁵ Department of Medical Biochemistry, Osaka University Graduate School of Frontier Bioscience, Suita, Osaka, 565-0871, Japan.
• ⁶ Comprehensive Heart Failure Center, University of Wuerzburg, Würzburg, 97078, Germany.
• ⁷ Department of Nuclear Medicine, University of Wuerzburg, Würzburg, 97078, Germany.