Background: Allergic rhinitis is the main symptom of pollinosis, relieved by non-specific treatment universally. This study aimed to find the changes of serum metabolites between the seizure and remission periods of pollinosis and provide assistance in the diagnosis and/or therapy.
Methods: Metabonomics based on 1H nuclear magnetic resonance (NMR) was used to study the 37 serum samples of pollinosis patients.
Results: We believed that the decreased levels of isoleutine, leutine, valine, 3-hydroxybutyric acid, allo-threonine, alanine, methionine, glutamine, lysine, glycine, l-tyrosine, histidine, phenylalanine, lactate, acetate, O-acetylcholine, creatine and creatinine and the increased level of N-acetylglutamine at the seizure stage were statistically significant.
Conclusions: Pollinosis could change the metabolic profiles of energy, amino acid and lipid in patients, which might be the diagnosis and/or prognosis markers for hay fever patients.
Keywords: Amino acid; Energy; FIDs, free induction decay; Lipid metabolism; Metabonomics; NMR, nuclear magnetic resonance; OPLS-DA, orthogonal partial least squares discriminant analysis; OSC-PLS-DA, orthogonal signal correction-partial least squares discriminant analysis; PBS, phosphate buffer solution; PCA, principle component analysis; Pollinosis; SD, standard deviation; SIT, allergen-specific immunotherapy; SLE, systemic lupus erythematosus; TCA, tricarboxylic acid cycle; TSP, 3-trimethylsilyl-propionic acid.