Emerging evidence for the essential role of hyaluronan in cutaneous biology

Jun Muto; Koji Sayama; Richard L Gallo; Koji Kimata

doi:10.1016/j.jdermsci.2019.01.009

Emerging evidence for the essential role of hyaluronan in cutaneous biology

J Dermatol Sci. 2019 Apr;94(1):190-195. doi: 10.1016/j.jdermsci.2019.01.009. Epub 2019 Mar 19.

Authors

Jun Muto¹, Koji Sayama², Richard L Gallo³, Koji Kimata⁴

Affiliations

¹ Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Japan. Electronic address: junmuto@m.ehime-u.ac.jp.
² Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Japan.
³ Department of Dermatology, University of California, San Diego, La Jolla, United States.
⁴ Advanced Medical Research Center, Aichi Medical University School of Medicine, Nagakute, Japan.

PMID: 30935779
DOI: 10.1016/j.jdermsci.2019.01.009

Abstract

Hyaluronan (HA), a linear non-sulfated glycosaminoglycan, participates in a variety of biological processes in the skin, such as cell-matrix interactions and activation of chemokines/cytokines, enzymes, and growth factors. In these activation events, HA acts as a damage-associated molecular pattern (DAMP). This review discusses the progress in functional research on HA, and its associated factors, in several aspects of cutaneous biology; e.g., immunity and wound repair.

Keywords: CD44; Damage-associated molecular pattern; Hyaluronan; TLR4.

Publication types

Review

MeSH terms

Alarmins / immunology
Alarmins / metabolism*
Animals
Cytokines / immunology
Cytokines / metabolism
Humans
Hyaluronic Acid / immunology
Hyaluronic Acid / metabolism*
Signal Transduction / immunology*
Skin / immunology
Skin / metabolism*
Wound Healing / physiology

Substances

Alarmins
Cytokines
Hyaluronic Acid